07 Jul SCORE2 Study for Retinal Vein Occlusion
This research study will compare the drugs Eylea® (aflibercept) and Avastin® (bevacizumab) for treatment of macular edema due to CRVO. Eylea is a drug that has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of macular edema due to CRVO. Avastin is a drug that has been approved by the FDA for the treatment of some types of cancer but it has not been approved for use in the eye. However, since 2006, Avastin has been used to treat a wide variety of eye problems, including CRVO. Avastin interferes with the growth of new vessels and prevents leakage of fluid from new blood vessels. Both Eylea® and Avastin® are proteins made in a laboratory and are thought to decrease the macular edema by decreasing the activity of vascular endothelial growth factor (VEGF) in the eye. Thus, these drugs are known as anti-VEGF drugs and are given via injections into the eye.
A total of about 360 people are expected to participate in this study nationally, including up to 10 at the Medical College of Wisconsin/Froedtert Hospital.
Potential participants may qualify for the study if they meet all of the inclusion criteria and none of the exclusion criteria.
Macular edema (swelling) due to a blocked vessel (CRVO) (will be verified by SCORE2 study doctor).
Aged 18 years or older.
Laser treatment for macular edema within 3 months.
Steroid injection in your eye for macular edema within 4 months.
Anti-VEGF injection in your eye for macular edema within 2 months.
Major eye surgery (including cataract surgery) within 4 months.
Problems with your eyes due to diabetes.
Additional Study Details
Study of Comparative Treatments for Retinal Vein Occlusion 2: A Multicenter, Prospective, Randomized, Phase III, Non-Inferiority Trial of Eye with Macular Edema Secondary to Central Retinal Vein Occlusion, Comparing Intravitreal Bevacizumab Every 4 Weeks versus Intravitreal Aflibercept Every 4 Weeks
Study ID: NCT01969708
Dr. Judy Kim, M.D.
Medical College of Wisconsin- The Eye Institute