Find a Clinical Trial

Find a Clinical Trial

All Clinical Trials (newest first)

Full Study Title: Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury (CITRIS-ALI) Summary Hypothesis 1A: Vitamin C infusion will significantly attenuate sepsis-induced systemic organ failure as measured by Sequential Organ Failure Assessment (SOFA) score, Hypothesis 1B: Vitamin C infusion will attenuate sepsis-induced lung injury as assessed...

Full Study Title: Gastrointestinal Tract Recovery in Patients Undergoing Open Ventral Hernia Repair Summary The purpose of this study is to determine whether Alvimopan (Entereg) in ventral hernia surgery patients is associated with accelerated gastrointestinal recovery and reduced length of hospital stay compared to placebo controls. Participant Eligibility Inclusion Criteria: Subjects...

Full Study Title: Clinical Evaluation of the RAVI-Guide Summary Hypothesis: The RAVI-Guide provides superior patient acceptability to the conventional lid speculum during intravitreal injections Aims: To compare patient acceptance and procedural complication rates of the RAVI-Guide with those of the conventional lid speculum and caliper approach Participant Eligibility Inclusion Criteria: Patients age...

Full Study Title: Cardiac Arrest Recovery EEG Study (CARES) Summary The purpose of the study is to collect EEG's as close to the cardiac arrest as possible using a standard hospital EEG machine and an investigational EEG device to help determine the neurological status of the cardiac arrest...

Full Study Title: A Post-Approval Study of the LINX® Reflux Management System Summary A Post-Approval Study of the LINX® Reflux Management System in a prospective, multicenter, single-arm study, with patients as their own control to monitor the safety and efficacy of the LINX implant procedure and device in...

Full Study Title: Haplo T-Cell Depleted Transplantation in High-Risk Sickle Cell Disease (HaploSCD) Summary This study is being done to determine the safety and outcome (long-term control) of a high-dose chemotherapy regimen followed by an infusion of CD34 selected (immune cells) stem cells from a partially matched adult...

Full Study Title: Evaluation of the Duration of Therapy for Thrombosis in Children (Kids-DOTT) Summary The Kids-DOTT trial is a randomized controlled clinical trial whose primary objective is to evaluate non-inferiority of shortened-duration (6 weeks) versus conventional-duration (3 months) anticoagulation in children with first-episode acute venous thrombosis. The...

Full Study Title: Photodynamic Therapy (PDT) for Benign Dermal Neurofibromas (NF1) Summary GENERAL OBJECTIVE The general objective is to assess the safety and efficacy of photodynamic therapy (PDT) in the treatment of neurofibromatosis 1 (NF1) tumors in the skin. SPECIFIC OBJECTIVE This is a light dose escalation pilot study...

Full Study Title: Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III (MISTIE III) Summary A phase III, randomized, case-controlled, open-label, 500-subject clinical trial of minimally invasive surgery plus rt-PA in the treatment of intracerebral hemorrhage (ICH). Participant Eligibility Inclusion Criteria: Spontaneous supratentorial ICH ≥ 30 mL diagnosed using radiographic...

Full Study Title: Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2) Summary SCORE2 is a multicenter, prospective, randomized, phase III clinical trial in which all participants enrolled will be followed for 12 months. SCORE2 is designed as a non-inferiority trial, with study eyes randomized to intravitreal...

Full Study Title: Using Multi-virus Cytotoxic T-cells Following T-Cell Depleted Allogeneic HPCT for Prophylaxis Against Epstein Barr Virus, Adenovirus, And Cytomegalovirus (ACE) Summary This protocol is a phase I study. Patients may be eligible for an infusion of Multi-virus Cytotoxic T Lymphocytes (CTL) if they received a T-cell...

Full Study Title: An Observational Registry of Abatacept in Patients With Juvenile Idiopathic Arthritis Summary The purpose of this study is to examine the long-term safety of Abatacept for the treatment of juvenile idiopathic arthritis (JIA) with particular in interest in the occurrence of serious infections, autoimmune disorders,...

Full Study Title: Double Cord Versus Haploidentical (BMT CTN 1101) Summary Hematopoietic cell transplants (HCT)are one treatment option for people with leukemia or lymphoma. Family members,unrelated donors or banked umbilical cordblood units with similar tissue type can be used for HCT. This study will compare the effectiveness of...

Full Study Title: A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based Summary The primary purpose is to assess the benefits and risks of changing from Cyclosporine or Tacrolimus to Belatacept between 6-60 months after kidney transplant. Participant Eligibility For more information regarding BMS clinical trial participation,...

Full Study Title: Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995 Summary Chronic granulomatous disease (CGD) is an inherited immune system abnormality in which bone marrow transplantation has been shown to be curative. However the risks of transplantation are high and not all patients with CGD may...

Full Study Title: Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204) (RICHI) Summary HLH, HLH-related disorders, Chronic Granulomatous (CGD), HIGM1, Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX) and severe LAD-I represent primary immune disorders that are typically fatal without Hematopoietic Cell...

Full Study Title: Patients Treated for Wiskott-Aldrich Syndrome (WAS) Since 1990 Summary Wiskott - Aldrich syndrome (WAS) is a rare serious medical condition that causes problems both with the immune system and with easy bruising and bleeding. The immune abnormalities cause patients with WAS to be very susceptible...

Full Study Title: Trial of Nelarabine, Etoposide and Cyclophosphamide in Relapsed T-cell ALL and T-cell LL Summary Nelarabine has shown significant activity in patients with T-cell malignancies. This study will determine the safety and maximum tolerated dose of the combination of nelarabine, cyclophosphamide and etoposide in patients with...

Full Study Title: ENDOvascular Interventions With AngioMAX: The ENDOMAX Trial Summary The primary objective of the study is to demonstrate that anticoagulation with bivalirudin results in fewer major bleeding complications compared with unfractionated heparin (UFH) in subjects undergoing peripheral endovascular interventions (PEI). The secondary objective is to identify...

Full Study Title: Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science (DHREAMS) Summary Congenital diaphragmatic hernia (CDH) is a birth defect that occurs when the diaphragm (thin sheet of muscle that separates the abdomen from the chest) does not form properly. When an opening is present in the...

Full Study Title: Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System Summary The primary objective of this study is to gather post market data on the Penumbra Ruby Coil System in the treatment of visceral artery aneurysms and arteriovenous malformations. This study is a prospective, multi-center...