Find a Clinical Trial

Find a Clinical Trial

All Clinical Trials (newest first)

Full Study Title: Haplo T-Cell Depleted Transplantation in High-Risk Sickle Cell Disease (HaploSCD) Summary This study is being done to determine the safety and outcome (long-term control) of a high-dose chemotherapy regimen followed by an infusion of CD34 selected (immune cells) stem cells from a partially matched adult...

Full Study Title: Evaluation of the Duration of Therapy for Thrombosis in Children (Kids-DOTT) Summary The Kids-DOTT trial is a randomized controlled clinical trial whose primary objective is to evaluate non-inferiority of shortened-duration (6 weeks) versus conventional-duration (3 months) anticoagulation in children with first-episode acute venous thrombosis. The...

Full Study Title: Photodynamic Therapy (PDT) for Benign Dermal Neurofibromas (NF1) Summary GENERAL OBJECTIVE The general objective is to assess the safety and efficacy of photodynamic therapy (PDT) in the treatment of neurofibromatosis 1 (NF1) tumors in the skin. SPECIFIC OBJECTIVE This is a light dose escalation pilot study...

Full Study Title: Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III (MISTIE III) Summary A phase III, randomized, case-controlled, open-label, 500-subject clinical trial of minimally invasive surgery plus rt-PA in the treatment of intracerebral hemorrhage (ICH). Participant Eligibility Inclusion Criteria: Spontaneous supratentorial ICH ≥ 30 mL diagnosed using radiographic...

Full Study Title: Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2) Summary SCORE2 is a multicenter, prospective, randomized, phase III clinical trial in which all participants enrolled will be followed for 12 months. SCORE2 is designed as a non-inferiority trial, with study eyes randomized to intravitreal...

Full Study Title: Using Multi-virus Cytotoxic T-cells Following T-Cell Depleted Allogeneic HPCT for Prophylaxis Against Epstein Barr Virus, Adenovirus, And Cytomegalovirus (ACE) Summary This protocol is a phase I study. Patients may be eligible for an infusion of Multi-virus Cytotoxic T Lymphocytes (CTL) if they received a T-cell...

Full Study Title: An Observational Registry of Abatacept in Patients With Juvenile Idiopathic Arthritis Summary The purpose of this study is to examine the long-term safety of Abatacept for the treatment of juvenile idiopathic arthritis (JIA) with particular in interest in the occurrence of serious infections, autoimmune disorders,...

Full Study Title: Double Cord Versus Haploidentical (BMT CTN 1101) Summary Hematopoietic cell transplants (HCT)are one treatment option for people with leukemia or lymphoma. Family members,unrelated donors or banked umbilical cordblood units with similar tissue type can be used for HCT. This study will compare the effectiveness of...

Full Study Title: A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based Summary The primary purpose is to assess the benefits and risks of changing from Cyclosporine or Tacrolimus to Belatacept between 6-60 months after kidney transplant. Participant Eligibility For more information regarding BMS clinical trial participation,...

Full Study Title: Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995 Summary Chronic granulomatous disease (CGD) is an inherited immune system abnormality in which bone marrow transplantation has been shown to be curative. However the risks of transplantation are high and not all patients with CGD may...

Full Study Title: Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204) (RICHI) Summary HLH, HLH-related disorders, Chronic Granulomatous (CGD), HIGM1, Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX) and severe LAD-I represent primary immune disorders that are typically fatal without Hematopoietic Cell...

Full Study Title: Patients Treated for Wiskott-Aldrich Syndrome (WAS) Since 1990 Summary Wiskott - Aldrich syndrome (WAS) is a rare serious medical condition that causes problems both with the immune system and with easy bruising and bleeding. The immune abnormalities cause patients with WAS to be very susceptible...

Full Study Title: Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science (DHREAMS) Summary Congenital diaphragmatic hernia (CDH) is a birth defect that occurs when the diaphragm (thin sheet of muscle that separates the abdomen from the chest) does not form properly. When an opening is present in the...

Full Study Title: Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System Summary The primary objective of this study is to gather post market data on the Penumbra Ruby Coil System in the treatment of visceral artery aneurysms and arteriovenous malformations. This study is a prospective, multi-center...

Full Study Title: Hematopoietic Stem Cell Transplant for Fanconi Anemia (FA) Summary The trial proposed is a single arm phase II treatment protocol designed to examine engraftment, toxicity, graft-versus-host disease, and ultimate disease-free survival following a novel cytoreductive regimen including busulfan, cyclophosphamide and fludarabine and anti-thymocyte globulin (ATG-...

Full Study Title: Targeted, Highly Sensitive, Non-Invasive Cardiac Transplant Rejection Monitoring Summary The investigator's primary goal is to quantitatively detect donor-specific DNA in plasma of organ transplant recipients. The investigator believe's that donor specific DNA can be isolated and quantified from transplant recipient serum. The investigator hypothesizes that...

Full Study Title: Family Health History in Diverse Care Settings Summary The outcome of this research will be a demonstration that family health history (FHH) risk data can be used efficiently to deliver more effective healthcare in geographically and ethnically diverse clinical care environments. Although FHH is a...

Full Study Title: A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) Summary This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications. Participant Eligibility Inclusion Criteria: Disorders affecting the hematopoietic...

Full Study Title: Efficacy of Isradipine in Early Parkinson Disease Summary The purpose of the study is to determine whether treatment with isradipine is effective in slowing the progression of Parkinson disease disability. Participant Eligibility Inclusion Criteria: Subjects with early idiopathic PD (presence of at least two out of three cardinal...

Full Study Title: Phase 2 Study of Montelukast for the Treatment of Sickle Cell Anemia Summary In this feasibility trial, the investigators will compare participants treated with montelukast and hydroxyurea to those treated with placebo and hydroxyurea for a total of 8 weeks. Participant Eligibility Inclusion Criteria: Diagnosis of HbSS, or...