Active Clinical Trials

Adrenocorticotropin hormone (ACTH 1-39) is a natural endogenous protein that shows intrinsic immunomodulation via melanocortin receptors absent corticotropism. Parenteral ACTH is a FDA approved biological agent (1978) for the treatment of MS exacerbations and for flares of other autoimmune diseases for over 40 years (RA,...

This is a randomized, double-blind, parallel group, placebo-controlled study designed to evaluate the efficacy and safety of a fixed 300 mg dose of tralokinumab administered subcutaneously in subjects with uncontrolled asthma despite the use of regular asthma controller inhaled medication and having a history of asthma exacerbations.Approximately...

Full Study Title: TGR-1202 + Ruxolitinib PMF PPV-MF PET-MF MDS/MPN Polycythemia Vera Resistant to Hydroxyurea Summary This is a Phase 1, open-label, study of TGR-1202, a PI3K delta inhibitor, administered together with ruxolitinib in patients with myeloproliferative neoplasms (specifically: polycythemia vera, primary myelofibrosis, PPV-MF or PET-MF) and MDS/MPN. Participant...

[box]Full Study Title National Ophthalmic Genotyping and Phenotyping Network, Stage 1 — Creation of DNA Repository for Inherited Ophthalmic Diseases[/box] Summary The main goal of this research is to understand genetic eye conditions and to identify the genetic factors responsible for causing such diseases. To help us in...

Age-related macular degeneration (AMD) is a disease associated with aging that gradually destroys sharp, central vision. The form of advanced AMD being studied in this clinical trial is commonly referred to as wet AMD (also called neovascular or exudative AMD). Wet AMD occurs when abnormal...

People with a retinal vein occlusion experience macular edema (swelling in the center of the retina, the thin light-sensitive tissue at the back of the eye) from blockage in a large retinal vein. This blockage is called a central retinal vein occlusion (CRVO). Retinal veins...

Full Study Title: Pediatric Alliance for International Neurogastrointestinal Functional Research Summary To explore the predictive value of alarm signs ("red flags") for a diagnosis of functional gastrointestinal disorders (FGID) in children. To assess the natural history of pain predominant functional gastrointestinal disorders (FGID) in newly diagnosed pediatric patients. To document...

Full Study Title: Pediatric Liver Database Summary The purpose of this study is to collect data to examine and characterize the clinical outcomes of pediatric patients diagnosed with any liver disease at Children's Hospital of Wisconsin. Participant Eligibility Inclusion Criteria: Under 18 years of age newly diagnosed with a liver disease, currently...

Full Study Title: Study of Ataluren in Nonsense Mutation Cystic Fibrosis (ACT CF) Summary This is a Phase 3, international, multicenter, randomized, double-blind, placebo-controlled, efficacy and safety study of ataluren in patients with nonsense mutation cystic fibrosis (nmCF) not receiving chronic inhaled aminoglycosides. Participant Eligibility Inclusion Criteria: Evidence of signed and...

Full Study Title: Cardiac Arrest Recovery EEG Study Summary The purpose of the study is to collect EEG's as close to the cardiac arrest as possible using a standard hospital EEG machine and an investigational EEG device to help determine the neurological status of the cardiac arrest patient...

Full Study Title: Study of Procoagulation Markers in Stroke Patients Summary The Insights on Selected Procoagulation Markers and Outcomes in Stroke Trial (I-SPOT): Response to Insulin Administration and Blood Glucose Control proposal is designed to accompany the Stroke Hyperglycemia Insulin Network Effort (SHINE) clinical trial, a Phase III...

Full Study Title: Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial Summary The Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial is a multicenter, randomized, controlled clinical trial of 1400 patients that will include approximately 60 enrolling sites. The study hypotheses are that treatment of hyperglycemic acute ischemic stroke patients...

Full Study Title: A Randomized Controlled of Enteral Nutrition in Septic Shock Summary Septic shock represents the body's dysregulated response to an infection, manifesting as persistent hypotension (mean arterial pressure < 70 mmHg) despite intravenous (IV) fluid resuscitation. Severe sepsis and septic shock are major healthcare problems, affecting...

Full Study Title: Trial of a Culturally-Appropriate Weight Loss Intervention for Overweight Latino Children Summary This project aims to conduct a unique, community-based intervention consisting of a randomized trial of a culturally-appropriate weight loss intervention for overweight Latino children in Milwaukee. The intervention promotes lifestyle changes through a...